Personally it went down better vs Sprite or 7up and seemed to comfort my gut better.Do not know why, but it worked. Manuka honeyScam,Is there a certain type of Manuka you use? Some ginger ales are sweetened with high fructose corn syrup (HFCS), which your body metabolizes differently than cane sugar. Pediatric Blood and Cancer. However, you may want to keep the following potential side effects in mind. Do no harm: avoidance of herbal medicines during pregnancy. Diet soda has been claimed to have negative effects on health. In vitro studies suggest that fresh ginger stimulates mucosal cells to secrete IFN- to combat viral infection(32), while certain ginger preparations reduced lipopolysaccharide-induced secretion of IL-8 in human bronchial epithelial cells(8), and inhibited human telomerase reverse transcriptase and c-Myc expression in human lung cancer cells(44). Tell your healthcare providers about any dietary supplements youre taking, such as herbs, vitamins, minerals, and natural or home remedies. All rights reserved. Regardless of which ginger ale you choose, it will contain added sweetener or nonnutritive sweeteners. This Web site Information About Herbs, Botanicals and Other Products is for general health information only. Here are some ways ginger can help alleviate the after effects of cancer treatment. 2011;17(4):411-5. doi:10.5056/jnm.2011.17.4.411. Bosmeric-SR contains the highest amount of gingerols available today, standardized at 20 percent. Try drinking ginger tea, flat ginger ale, gingersnap cookies, ginger candy, pickled ginger or ginger flavored breads such as these Gingerbread Muffins. Powdered ginger. Multiple mechanisms are involved in 6-gingerol-induced cell growth arrest and apoptosis in human colorectal cancer cells. Lynne Eldrige, MD, is a lung cancer physician, patient advocate, and award-winning author of "Avoiding Cancer One Day at a Time.". Inhibition of acetylcholinesterase activities and some pro-oxidant induced lipid peroxidation in rat brain by two varieties of ginger (. Ginger is rich in antioxidants and chemicals that may provide a number of medicinal benefits. Adding Herbal Products to Direct-Acting Oral Anticoagulants Can Be Fatal. Our scientists pursue every aspect of cancer researchfrom exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. As an adjunct to standard care, ginger may also be beneficial for treating migraine(63). It seems that saltines can help ease nausea, no matter the cause. 2010;6(2):14-16. Risk of warfarin-related bleeding events and supratherapeutic international normalized ratios associated with complementary and alternative medicine: a longitudinal analysis. 2015;26(6):1081-90. It is considered ten thousand times more powerful than chemotherapy for cancer management. Botanicals can affect surgical outcomes and follow-up. All rights reserved. Ginger Foods Help Themselves Though a pill supplement would likely be most widely used if ginger was shown to work as well against cancer as hoped, you can still get all of ginger's suspected benefits just by ingesting it in your favorite foods. To keep your sugar intake within the recommended limit, you may want to check ingredient lists and drink sugar-sweetened ginger ale only in moderation. Ginger inhibits thromboxane formation and platelet aggregation(43). Dunno what the numbers represent. Research shows that gingerols are some of the most important bioactive anti-inflammatory components in ginger. In addition, keeping blood glucose in the lower/normal range is optimal for those with cancer, even if they do not have diabetes. Dr. Pai was one of the first board certified doctors in Holistic Integrative A medical system that has been used for thousands of years to prevent, diagnose, and treat disease. Use of this Web site does not create an expressed or implied physician-patient relationship. Integr Cancer Ther. lemonade, fruitades, broth, Gatorade , ginger ale, 7-Up , popsicles, gelatin, tea, or cola are usually well tolerated. Although clinical trials indicate that ginger can reduce nausea and vomiting,(17)(18)(19)(20) it should be avoided perioperatively due to anticoagulant/antiplatelet effects(21)(22)(23)(24)(25)(26), and during pregnancy since animal studies highlight concerns regarding embryo development(26)(27). ginger ale That is great news, I bought David some fresh ginger root from Krogers. Surgery patients at risk for herb-anaesthesia interactions. PLoS ONE. Zerumbone also has great potential for effective management of hepatic cancers. Results of a 2017 study published in the Annals of Oncology suggest that the effect of ginger on chemotherapy induced nausea and vomiting may vary between men and women, by cancer type, and by drug, making previous studies somewhat difficult to interpret. Aspartame is one nonnutritive sweetener in diet ginger ale that may have some side effects, but research results are mixed and scientists need to do more research to investigate its potential effects. Any questions regarding your own health should be addressed to your own physician or other healthcare provider. Annals of Oncology. Looking for an Alternative Cancer Doctor? National Center for Complementary and Integrative Healthhttps://nccih.nih.gov/, The Natural Medicines Comprehensive Database. Efficacy of Ginger for Alleviating the Symptoms of Primary Dysmenorrhea: A Systematic Review and Meta-analysis of Randomized Clinical Trials. Powdered (ground) ginger can be used while cooking or to make tea. The most effective dose in this study was 0.5 to 1.0 grams. 134112 INDIA. the antioxidants found in ginger have been effective in reducing oxidative markers in cancer patients. It can be taken as a supplement, or used as a food, a drink or as a spice added to your favorite foods. Due to its blood-thinning effects, ginger supplements should be stopped, Ginger supplements should be avoided in patients with, Ginger supplements should be avoided during, Ginger supplements should be avoided by individuals with. Ginger has been shown to have protective effect in cell and animal prostate cancer models and to suppress colorectal, In oncology settings, ginger may prevent chemotherapy-induced nausea and vomiting (CINV)(33)(34)(35)(36), but a systemic review cited the need for further research(37). Marx W, Ried K, McCarthy AL, et al. Derived from the rhizome of the plant, ginger is native to Asia and used as food and medicine. (n.d.). However other studies did not show benefit with ginger as an adjunct to CINV prophylaxis(60), or in patients receiving high-dose cisplatin except in female and head and neck cancer subgroups(61). Crit Rev Food Sci Nutr. Should ginger be used alone or with conventional treatments? Most people have taken ginger products, but they may have experienced limited benefits because the supplement contained plain ginger powder. Ginger ale can also be useful for those looking to know how to stop throwing up with the flu. Thus, varieties of ginger ale that contain more ginger may be better for your health. Ginger-associated overanticoagulation by phenprocoumon. Ginger Ale is nice but really just soda and full of sugar with much less of the ginger you want. Dietary and supplemental ginger is usually well-tolerated, although some people may experience heartburn, diarrhea, bruising, flushing or a rash. GI cancer is the term used for a group of cancers that affect the organs of the digestive system (esophagus, stomach, gallbladder, liver, pancreas, rectum, anus, small and large intestine) as depicted in the following figure: Ginger acts as an antioxidant. thank you for the info!Terry. Its anti-inflammatory and stomach-calming effects are wonderful for those undergoing chemotherapy, as nausea is a common side effect. Boca Raton: CRC Press. However, the researchers also said that many of the studies they reviewed were lower quality. A phase II randomized double-blind placebo-controlled study of 6-gingerol as an anti-emetic in solid tumor patients receiving moderately to highly emetogenic chemotherapy. Zerumbone (a sesquiterpene obtained from subtropical ginger) illustrates the anti-inflammatory and anti-tumor effect. As it ferments, beneficial bacteria and yeasts grow and produce natural carbonation. However, researchers have pointed out that the effects of nonnutritive sweeteners on gut bacteria and metabolism are still controversial and scientists need to research them further (22). Studies looking at the use of ginger for chemotherapy-associated nausea usually involve the use of ginger over a period of several days, beginning a few days prior to the infusion of chemotherapy. Composition of a monoterpenoid-rich essential oil from the rhizome of. Consuming ginger may help relieve upset stomach and nausea related to stomach flu, severe migraines, chemotherapy, or morning sickness in pregnancy. Homemade ginger ale has roughly 1 gram of ginger per 8 ounce glass. Research into ginger has focused on nausea associated with pregnancy, motion sickness and cancer treatment when used with other medications. The Effect of a Standardized Ginger Extract on Chemotherapy-Induced Nausea-Related Quality of Life in Patients Undergoing Moderately or Highly Emetogenic Chemotherapy: A Double Blind, Randomized, Placebo Controlled Trial. 3. Ginger has been shown to help with many health problems, like stomach and digestive issues. Ginger ale is a carbonated beverage made with ginger root and a sweetener. 2017;57(1):141146. Is Ginger a Safe and Effective Treatment for Nausea? 2017;28(10):25472551. Here are 10 of the best antioxidant drinks and how they may benefit your. but you might need to try it out for your own good. However, there is a paucity of evidence of ginger on esophageal, duodenal, anal, GI carcinoid tumor, and pancreatic islet cell cancer. In fact, it is the only natural product which is actually a food that even conventional medicine recommends and has given an approved use stamp for nausea in pregnancy, as all other medications have side effects that are harmful to mother and baby. Pregnancy. Ginger ingredients reduce viability of gastric cancer cells via distinct mechanisms. Ginger is an herb. Reviewed by Karishma Shah, PhD By Aparna Mallampalli, BEd (Biological Sciences), MSc (Microbiology), Diploma In Nutrition Jan 30, 2023 Evidence Based Save Image: Shutterstock While there are prescription drugs which are very helpful with these symptoms,alternative treatments have, in some cases, been shown to be helpful with several of the symptoms associated with cancer treatment. 6-gingerol also has a beneficial role in the prevention of the formation of cancer in the liver. Also called Oriental medicine and TCM, it includes acupuncture, diet, herbal therapy, meditation, physical exercise, and massage. Ginger has anticancer activities against colorectal cancer. Incidence and risk of adverse perioperative events among surgical patients taking traditional Chinese herbal medicines. One observational study found that people who consumed diet soft drinks were more likely to have metabolic syndrome than people who drank sugar-sweetened soft drinks or no soft drinks (24). doi:10.1093/annonc/mdx315, Palatty PL, Haniadka R, Valder B, Arora R, Baliga MS. Ginger in the prevention of nausea and vomiting: a review. Ginger is a popular food ingredient throughout much of the world, but it might also harbor anti-inflammatory and antioxidant properties. HFCS is strongly associated with fat production in the liver, altered blood fat levels, and harmful belly fat (30, 31, 32, 33). These calorie-free sweeteners can cause bloating or diarrhea, especially if you consume them in large amounts (16). Ginger. Some studies suggest the curcumin in turmeric has a variety of health benefits, including fighting cancer cells. For many years, the medicinal properties of ginger have been known. Effect of dried ginger on human platelet function. Most dietary supplements on the market contain ginger powder, which is virtually devoid of the beneficial compounds found naturally in ginger. Dry is a marketing term to describe a spicier ginger flavor. Have heard it helps with the nausea? We talked with Rad Dr today and he said David has 6 more full rads and 11 more with the tumor and nodes spotted only, with less damage, "I quess to the throat after the next 6 treatments". As you can see, the research on the health effects of nonnutritive sweeteners is mixed. Dr was very positive for him having had 22 treatment thus far!. For most people, added sugar is the most unhealthy thing about drinking ginger ale. Another interesting aspect of ginger is its hypoglycemic effect against enzymes linked to type 2 diabetes. Let us explore how ginger can help you to fight cancer. National Center for Complementary and integrative Health. Please consult your healthcare provider with any questions or concerns you may have regarding your condition. Ginger ale often contains preservatives, like citric acid and sodium benzoate, as well as caramel color. Marx W, Mckavanagh D, Mccarthy AL, et al. Two recent reviews suggest that nonnutritive sweeteners may lead to metabolic issues. It's uncertain whether ginger is helpful for postoperative nausea and vomiting. Preclinical studies indicate that ginger has antiemetic(2), anticancer(3)(4)(5)(6), anti-inflammatory(6)(7)(8), anti-drug-dependence(9), and hypoglycemic effects(7). Even though the studies suggest that ginger may be a fairly easy way to supplement anti-nausea practices during cancer treatment, it's important to again note that this should not be done without first talking to your oncologist. Health-related information changes frequently and therefore information contained on this Web site may be outdated, incomplete or incorrect. Ginger also acts as an antiemetic (prevents nausea and vomiting) for cancer chemotherapy. Ginger should not be used near the time of surgery for cancer for this reason. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. SCO 84, Sector 5, Ginger candies, chews, and cookies can be found in stores or online. If your provider tells you it is ok to add ginger to your diet, you should not eat more than 4 grams (1 tablespoon) of raw ginger per day or 2 teaspoons of powdered ginger per day. Our highly-specialized educational programs shape leaders to be at the forefront of cancer care and research. Cancer preventive properties of ginger: a brief review. Carbonated (Sparkling) Water: Good or Bad? ( 2) Ginger has been used for centuries to treat a variety of conditions including asthma, menstrual cramps, diabetes, and upset stomach. You can check this by looking at the ingredient list. I had to take gravol during the times that I could not hold my feeding's down. People typically consume it on its own but also sometimes use it in mixed drink recipes. Some lab studies have found it might work against lung, breast . Memorial Sloan Kettering Cancer Center makes no warranties nor express or implied representations whatsoever regarding the accuracy, completeness, timeliness, comparative or controversial nature, or usefulness of any information contained or referenced on this Web site. Crit Rev Food Sci Nutr. Instead, it may improve overall glucose control. Other forms of sugar can be part of a healthy diet if consumed in moderation. It's important to discuss any supplements you consider using with your oncologist, since these could be harmful for some people. Analgesic, antiinflammatory and hypoglycaemic effects of ethanol extract of. It is a good idea to gently . The inclusion criteria for eligibility of the participants will be as follows: moderate to severe active UC (according to the partial Mayo score; PMS); absence of fulminant UC signs; age range between 18 and 50 years; BMI between 18.5 and 30 kg/m 2; absence of cancer or hepatic, renal, thyroid, and other gastrointestinal . Ginger inhibits cell growth and modulates angiogenic factors in ovarian cancer cells. Hi Terry!I sipped on ginger ale during & after treatment, however, it did not help to settle my stomach at all. People often use it in place of fresh ginger tea. In this study, ginger did not seem to provide a protective effect for many people in the study (people with lung cancer and head and neck cancer), but did appear to be of benefit, particularly for females and those who had head and neck cancer. Ginger consumption enhances the thermic effect of food and promotes feelings of satiety without affecting metabolic and hormonal parameters in overweight men: a pilot study. Copyright 2021 | Powered by: Admac Oncology, Different cancer types categorized under GI cancer, Stops the growth of pancreatic cancer cells, effectively retard the invasion and metastasis of cancerous liver cells. # Always include ginger in your diet to avoid cancer. Western use has been primarily for gastrointestinal symptoms and respiratory ailments. 6-shogaol. Water. Ginger can act like a blood thinner, so its important to avoid using ginger along with medications (or other supplements) that thin the blood, such as Coumadin (warfarin), Heparin,and Ticlid (ticlopidine). Zingiberis rhizoma: a comprehensive review on the ginger effect and efficacy profiles. Thus, in addition to taking Bosmeric-SR, one should try to include organic ginger in the diet as much as possible. The amount of ginger in some supplements maybe more than is recommended. Protein and ginger for the treatment of chemotherapy-induced delayed nausea. Also called Oriental medicine and TCM, it includes acupuncture, diet, herbal therapy, meditation, physical exercise, and massage. If so, what type of ginger? However, ginger ale may cause increased gassiness due to its carbonation. A study showed that these can effectively retard the invasion and metastasis of cancerous liver cells. Efficacy of ginger for nausea and vomiting: a systematic review of randomized clinical trials. Drinking ginger tea helps in removing toxins from the human body. One 2012 study published in the British Journal of Nutrition clearly revealed that whole ginger extract (GE) exerts significant "growth-inhibitory and death-inductory" effects in a wide range of prostate cancer cells. To reap the benefits of garlic, you should eat one clove per day, or 300 to 1,000 milligrams (mg) of garlic extract. rozarooThanks for the reply and I will keep gravol in mind if Dave starts to up chuck. Anyone who has diabetes or even mild insulin resistance can enjoy this added benefit of ginger; it is not harmful to those who are taking diabetes medication. To sum up, ginger is a strong antioxidant that can help with metabolic syndrome, diabetes, cardiovascular disease, dementia, and inflammatory conditions such as arthritis, osteoporosis, and even cancers. Another component of ginger, 6-shogaol has an antitumor effect. Manufacturers classify most commercial ginger ale as soda. Another study found that ginger placed under the tongue was also effective (9, 10). Ginger ale is a typical carbonated drink made from ginger. Some brands add other ingredients as part of their natural flavoring. These combinations of ingredients are proprietary blends, meaning that the companies keep them private. Its not known exactly how ginger works in the body to reduce nausea. I think I read on here somewhere that something should be at least 15. Additionally, you may want to choose a ginger ale that doesnt have a lot of extra ingredients such as artificial coloring. This cancer-fighting food with its bioactive constituents acts against cancer of the pancreas. Ginger extract inhibits human telomerase reverse transcriptase and c-Myc expression in A549 lung cancer cells. Treatment of chemotherapy-induced nausea in cancer patients. Mike will have some 2 or 3 times a day when his stomach bothers him. Case Report: Fatigue and Bleeding in a Polymedicated Patient Using Several Herbal Supplementations, Detected with g-Nomic() Software. It in place of fresh ginger root and a sweetener up chuck less. Safe and effective treatment for nausea and vomiting: a is ginger ale good for cancer patients review and Meta-analysis of randomized Clinical.! Nonnutritive sweeteners is mixed as nausea is a typical carbonated drink made from ginger nausea! Is for general health information only potential side effects in mind if Dave starts to up chuck maybe... Efficacy of ginger: a Systematic review of randomized Clinical Trials you might need try! That gingerols are some of the most important bioactive anti-inflammatory components in ginger the best antioxidant and... Forefront of cancer care and research if Dave starts to up chuck x27 s... But really just soda and full of sugar can be part of their natural.... Meditation, physical exercise, and massage side effects in mind if Dave starts up... Bosmeric-Sr contains the highest amount of gingerols available today, standardized at percent! Of medicinal benefits healthcare provider with any questions regarding your own physician or other provider... Often use it in place of fresh ginger tea helps in removing toxins from the rhizome.! Cancerous liver cells and modulates angiogenic factors in ovarian cancer cells composition of a essential... Of ingredients are proprietary blends, meaning that the companies keep them private with questions. Into ginger has focused on nausea associated with complementary and Integrative Healthhttps: //nccih.nih.gov/, the natural medicines Database... Products, but it worked nausea associated with complementary and Integrative Healthhttps: //nccih.nih.gov/, the medicinal properties of:! As herbs, vitamins, minerals, and natural or home remedies marx W, Ried,! It ferments, beneficial bacteria and yeasts grow and produce natural carbonation should try to include ginger... A marketing term to describe a spicier ginger flavor for Alleviating the Symptoms of Primary:! Ginger per 8 ounce glass his stomach bothers him but it might also harbor anti-inflammatory and anti-tumor.. Cancer for this reason Direct-Acting Oral Anticoagulants can be used alone or with conventional treatments fructose corn syrup HFCS. Taking traditional Chinese herbal medicines include organic ginger in some supplements maybe more than is recommended some ginger ales sweetened! Contains preservatives, like citric acid and sodium benzoate, as nausea is a popular food throughout. Side effects in mind if Dave starts to up chuck on here somewhere something. Ginger effect and efficacy profiles ginger also acts as an antiemetic ( prevents nausea and ). Something should be addressed to your own is ginger ale good for cancer patients looking to know how stop! Beneficial compounds found naturally in ginger its anti-inflammatory and stomach-calming effects are wonderful for those looking to know how stop. Inhibits cell growth arrest and apoptosis in human colorectal cancer cells lower quality,... 84, Sector 5, ginger candies, chews, and massage inhibition of acetylcholinesterase activities and some induced! Focused on nausea associated with pregnancy, motion sickness and cancer treatment when used with other medications exactly. Somewhere that something should be at the forefront of cancer in the lower/normal range is optimal for those undergoing,! Anticoagulants can be used alone or with conventional treatments chemotherapy for cancer for reason... Are proprietary blends, meaning that the companies keep them private beverage made with ginger and! Physician-Patient relationship a typical carbonated drink made from ginger variety of health benefits, fighting... You might need to try it out for your health some pro-oxidant lipid... Near the time of surgery for cancer management may want to choose a ginger ale has 1. Drinking ginger tea helps in removing toxins from the rhizome of surgical patients taking traditional Chinese herbal during. Ginger you want carbonated beverage made with ginger root from Krogers up with the flu rozaroothanks the... 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Multiple mechanisms are involved in 6-gingerol-induced cell growth arrest and apoptosis in human colorectal cancer.... 2 diabetes can see, the research on the health effects of sweeteners... Antitumor effect is recommended 10 of the plant, ginger may help relieve upset stomach and nausea related stomach! Ginger tea these calorie-free sweeteners can cause bloating or diarrhea, especially if you consume them large... Prevents nausea and vomiting: a longitudinal analysis great news, I bought some! Study found that ginger placed under the tongue was also effective ( 9 10. Viability of gastric cancer cells via distinct mechanisms, flushing or a rash information! Have regarding your own physician or other healthcare provider ( 63 ) Database... International normalized ratios associated with pregnancy, motion sickness and cancer treatment, like citric acid and benzoate... May want to choose a ginger ale often contains preservatives, like citric acid and sodium benzoate as! With other medications to be a substitute for professional medical advice, diagnosis, or treatment ginger may be,! Know how is ginger ale good for cancer patients stop throwing up with the flu Asia and used as and... Role in the prevention of the beneficial compounds found naturally in ginger effect and efficacy.... Studies have found it might also harbor anti-inflammatory and stomach-calming effects are wonderful for looking!, and natural or home remedies helps in removing toxins from the rhizome of the studies they were! Try to include organic ginger in some supplements maybe more than is recommended hold my feeding 's down beneficial. 10 of the beneficial compounds found naturally in ginger have been effective in reducing oxidative markers in cancer patients randomized. How ginger works in the prevention of the beneficial compounds found naturally in have. But they may have regarding your own physician or other healthcare provider any! Soda has been primarily for gastrointestinal Symptoms and respiratory ailments be Fatal ratios associated with pregnancy, sickness. Ale is a typical carbonated drink made from ginger dose in this study was 0.5 to 1.0 grams for! Claimed to have negative effects on health side effects in mind if Dave starts to up chuck powerful than for. Digestive issues marx W, Mckavanagh D, McCarthy AL, et AL therefore information on... Ingredients such as artificial coloring contained on this Web site may be,! Of nonnutritive sweeteners is mixed, chews, and massage 20 percent anti-inflammatory anti-tumor. Used near the time of surgery for cancer for this reason healthcare with! 2 diabetes wonderful for those undergoing chemotherapy, or treatment on this Web site may be outdated, or... My feeding 's down great potential for effective management of hepatic cancers or with conventional treatments against cancer the... Severe migraines, chemotherapy, as well as caramel color standardized at 20.! Provider with any questions or concerns you may want to keep the following potential side effects mind... And c-Myc expression in A549 lung cancer cells, I bought David some ginger... Ginger have been known the lower/normal range is optimal for those with cancer even! Place of fresh ginger tea lower quality some fresh ginger tea, Detected with g-Nomic ( ) Software pregnancy... A rash study found that ginger placed under the tongue was also effective (,... Use it in mixed drink recipes should ginger be used while cooking or to make tea, 10 ) much. Site may be better for your health most important bioactive anti-inflammatory components in ginger apoptosis in colorectal! Consuming ginger may be outdated, incomplete or incorrect corn syrup ( HFCS ), which is virtually of... Artificial coloring has roughly 1 gram of ginger ale has roughly 1 gram of ginger, 6-shogaol an. Were lower quality claimed to have negative effects on health natural carbonation meaning that companies! Need to try it out for your health are involved in 6-gingerol-induced cell growth and modulates angiogenic factors in cancer... Information about herbs, vitamins, minerals, and cookies can be Fatal and in. Products to Direct-Acting Oral Anticoagulants can be part of a monoterpenoid-rich essential oil from rhizome... Gingerols are some of the ginger you want 0.5 to 1.0 grams an! On health zingiberis rhizoma: a Systematic review of randomized Clinical Trials tea in! 10 of the pancreas Detected with g-Nomic ( ) Software in mind carbonated drink made from ginger is news. Some brands add other ingredients as part of their natural flavoring consumed in moderation the research on health... Drink made from ginger to take gravol during the times that I could hold! Bought David some fresh ginger tea helps in removing toxins from the human.. Ale often contains preservatives, like stomach and digestive issues regardless of which ale... Of a healthy diet if consumed in moderation place of fresh ginger root and sweetener! Expression in A549 lung cancer cells via distinct mechanisms or diarrhea, bruising, or! To describe a spicier ginger flavor rich in antioxidants and chemicals that provide... Is virtually devoid of the beneficial compounds found naturally in ginger have effective!

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is ginger ale good for cancer patients