I started the estrace (I am doing pills) 2mg 2x/day 7 days after a positive OPK, and then continuing throughout stims. Estrogen Priming Protocol - Infertility Inspire Finding a Resolution for Infertility IUI / IVF and high-tech procedures Finding a Resolution for Infertility Infertility Support Community in Partnership with RESOLVE Join Inspire Create a Post Estrogen Priming Protocol blossom34 (Inactive) Sep 23, 2010 5:34 AM Lets start with how much gonadotropin to take. Has anyone had any experience with the Estrogen Priming Protocol? The deadline for sending in seeds was October 15th, but there are still plenty of ways to get involved. I'm not doing IVF, however. IVF#1 with ICSI spring 2006 - 3 eggs retrieved, one transferred - BFN Another set of investigators looked at a variation of the same question. Looking for info/success stories with Estrogen priming protocol with DOR. It is used for low/poor responders -- often women with high FSH and/or over 35 years of age. ER sept 29th - 11 follicles, 9 eggs retrieved If ok, then start stimulation The many repeat bloodworks & ultrasoundsLast stimulation shot + triggerRetrievalSo I started my process in the mid-September and my retrieval happened in early NovemberAlso, I was on MicroFlare protocol, so I am not sure what other medications you might be taking. I'm starting with this IUI and then will see how I respond and move forward from there. I mean, you might be lucky. There are two downsides to this protocols: The long duration of injections (they start the previous cycle) and. This educational content is not medical or diagnostic advice. On CD2 I started 300 Gonal F and 150 Menopur. Anyhoo, I am just curious whose done this and what the difference was in terms of their egg numbers and quality.especially if anyone used it for quality. i had success with DE. Have done 3 IUI's - 2 w. clomid and 1 with Gonal - F. I had a hyrdo on my left tube which had been removed and no left ovary to be found :( But I do have a good right tube & ovary. Ugh, that made me feel like I was hit by a truck. This website uses cookies for functionality, analytics and advertising purposes as described in our, http://www.fertstert.org/article/S0015-0282. Im very new to this, have never done an IVF cycle but was hoping to start soon. I starts on day 1 of my cycle for 25-26 days of estrace.. Not sure why.. undefined will no longer be visible to you including posts, replies, and photos. During my IVF cycle (still in the middle of it), Dr. K's 21 day estrogen priming protocol with 300 iu menopur seemed to have done the trick with 29 follicles (19 of which were bigger). They are generally used for suppression in Long Lupron Protocols. I'm 45 and having a hard time accepting the reality of not having my own bio child. Did they think estrogen helped with even follicle growth or egg quality? Those 2 were my worst cycles. Gardening, outdoors, country living, my furbabies, my DH, anything but working! First, the analysis was retrospective and not prospective. I was on BCP for 20 years (have been off for several now) and it took me a long time to normalize after coming off them. Of course, during a regular cycle most women naturally produce only a single mature egg. I did EPP my second round of IVF. Waiting for that call is sooo stressful! He also said he would start with BCPs to suppress ovulation- he explained why, but at my age that just doesn't sound like a good idea to be suppressing anything. Had two follicles but one disappeared day of egg retrieval. But I also realize I'm not a dr and should probably listen to their advice! Ultimately there are two protocol strategies doctors will use: either the Long Agonist or Antagonist protocols. Get Ready for a New Season of Gardening -Choose from Tomatoes, Peaches, Corn, Zinnias & More! I did EPP, using a climara patch every other day starting day 8 after ovulation until period came. No BCP - started my period, did cycle day 2 testing FSH was good (I had high a FSH of 15 so EPP helped that) then started meds. I am anxious to see if my dr recommends it. I am 37 with diminished egg reserve and a high estrogen level and need a doctor who will be more aggressive with the volume of meds so I can hopefully achieve my e, I need help. I have seen a lot about EPP being used for poor responders (which I am not) and a little about it being used for egg quality. Until then, its hard to make a definitive call on whether these drugs work. One well regarded study determined that amongst most IVF patients, those taking over 150 IUs per day of gonadotropin had higher rates of success than those who took less. It all depends on your tests and what specific information they have for you. How did it go with the EPP? Any info welcomed!! In patients over 40 years old, after probably the 3rd round, the cumulative live birth rates are not increasing. Hey ladies, I am about to start my second IVF cycle and this time instead of priming with birth control I am doing estrogen tablets 2mg twice a day as well as a pump of androgel. This drug acts directly on the follicles to start this process and causes (italics) OHSS. Northwestern Medicine. Started with our current RE in April 2017; diagnosis is unexplained infertility (everything came back fine for both me and my husband on all tests). The idea is to give your body about 5-7 days of Estrogen Priming. The one thing I will say is that I am definitely stimming much longer than I did for my IVF #1 which did not have the esrogen. In the case of the fresh transfers, you can clearly see a similar effect to what investigators found above: success rates drop with more drug. FertilitySmarts is your go-to source for medically accurate info and expert-sourced opinions on all aspects of fertility. Best of luck choosing. After seven long years consumed by infertility I am finally moving forward, wishing my son was with me, but grateful for the two children I have here with me. 2005-2023Everyday Health, Inc., a Ziff Davis company. Estrogen Priming Protocol- EPP Experiences. There is a ton of data out there for 'younger' women 35-42 with fertility issues but I'd like to be able to g, I was taking Estrace and Androderm patch when I went in for my base sonogram and they said I was already ovulating! Has anyone with failed IVF stim tried mini/micro IVF? The answer lies in the drug the protocol uses to trigger the eggs to mature so that they can be retrieved. Did acupuncture, Chinese herbs, modified diet, re-tested and FSH was 7 / Estradiol 47/ AMH .4 The misoprostol was not expensive; on average, it's about $30. I have hypothalamic anvolution, DH normal. 10 retrieved, 6 mature, 6 fertilized (half with ICSI), transferred two 8-cell embryos on day three (both with moderate fragmentation, graded B and C-), the four remaining arrested by day 5. Doing mild IVF - and wondering how that is going to work as the test today was that i only had one follicle visible - Any idea what to expect? Dr Sher says "oestrogen priming of FSH receptors has been reported to slow premature follicular development and to promote granulosa cell FSH receptor induction". Recent Topics Most experts believe these women just dont seem to respond to increased doses and so above a pretty low threshold of gonadotropin, success rates dont seem to budge much. So it seems to me it's time to change the protocol, do another cycle and gather more inform, I am 36 years old. If you feel a message or content violates these standards and would like to request its removal please submit the following information and our moderating team will respond shortly. So it's a low dose of Lupron, but not necessarily low doses of stims overall. A flare cycle may involve OCP or estrogen-only pretreatment, but the key is that a GnRH agonist (Lupron, Suprefact, or Synarel) will be started at exactly the same time as the stimulating medication. Check out this video to learn more about the. I did a phone consult with Sher and he suggested the conversion protocol to me as well. The Finding a Resolution for Infertility Support Community connects patients, families, friends and caregivers for support and inspiration. But I am sure they know what they are doing at CCRM. Good luck. Women with premature ovarian failure (POF) or diminished ovarian reserve (DOR) tend to have lower success rates with traditional IVF protocols. What Research Says About Stress as a Cause of Infertility, 7 Ways to Help Overcome Grief after Pregnancy Loss, Sometimes Getting Pregnant is Not the Issue, From Eggs to Blastocysts: Understanding IVF Attrition, Let's Stop Arguing About Whether or Not Stress Causes Infertility, Gift Ideas For Someone Experiencing Infertility, FertilitySmarts Explains Estrogen Priming. I just want to be knowledgeable and advocate for myself bc like many others on here, being over 40 I there's no time to waste-. We're banking this cycle and testing them with the biopsies from the next. As a result, in fresh transfers the effects of gonadotropin are still present in a womans body her hormones are in flux and, as result, the uterus is less prepared to absorb the embryo upon transfer. But there is one more protocol to consider: a flare cycle. This time she is switching me to EPP w/ 100 Follistim/150 Menopur. The dr decided to put a halt to the process for that month. DS was born June 22nd, 2007!!!!! Once multiple follicles start growing, its important that they are not ovulated before they can be collected in an egg retrieval. Some reproductive endocrinologists will change the treatment strategy based on the number of follicles available at the start of the cycle. With these patients, a pre-treatment cycle, known as estrogen priming, is performed prior to stimulation to help to collect an adequate number of mature eggs during the ovarian stimulation cycle. Good Morning. Hence we see mini-IVF protocols used at places like New Hope Fertility in NYC (http://www.newhopefertility.com/?topic=minimal-stimulation-mini-ivf) and the Infertility Center of St Louis (http://www.infertile.com/closlook/biograph.htm); and, Hello, Cetrotide was added CD9. With this you get results by day-3 and can transfer embryos at that time. My clinic doesn't like it. Cool.let me know what he says if you would please. They are generally used for suppression in Long Lupron Protocols. Find other members in this community to connect with. Its effective, but expensive, and raises the risk of OHSS. I am just hoping between the estrace and progesterone my period holds off until next Thursday! Long time reader, first time poster. My friends did this estrogen priming protocol and highly recommend it and were successful. 2 Girls!! This typically happens with conventional insemination where the egg and the sperm are placed in the same culture environment for fertilization Many customers have had positive experiences ordering from them, and their customer service has been praised for keeping buyers updated on order status. This time I have to use 450iu of Gonal/follistem and 150iu of Menopur each day and I pay out of, I recently attempted my first IVF. Outdoor sports and activities of all types. No it's not a "low dose" protocol exactly. I credit the advice I received on this forum both from members and from experts, my infertility doctor and my push for the estrogen priming protocol for the family that I have today. BFP October 22!!!! IUI pregnancy rates can only be slightly better than the natural live birth rate offered by Mother Nature which is 10-15%. From what I've seen on the boards, ladies get a higher number and higher quality. Has anyone started a Jun fresh IVF group? Twins & Multiples: Your Tentative Time Table. However, that information will still be included in details such as numbers of replies. Can you try to conceive the cycle that you estrogen prime? FertilitySmarts is a part of Janalta Interactive. I am about to embark on my IVF#6 cycle (1st time at CCRM)- I've always done OCP/BCP before my IVF stim cycle(antagonist) and have produced between 15-19 eggs each time. The stim phase was just like a usual antagonist cycle. It seems less is more in my case!! You can be assured it is a good protocol. [lcurtis8] For my first IVF they had me on Lupron. IVF #2, we did estrogen priming, Follistim, Menopur, Tev Tropin (human growth hormone), Cetrotide. I also did human growth on 2 cycles and didn't help a bit. I understand the idea for the patch is to help time the growth of follicles vs. increase the number? Estrogen priming is usually matched with an antagonist to prevent ovulation. Create an account or log in to participate. Privacy Policy - Below is data collected on over 3,000 cycles for each protocol approach in the Netherlands. This clinic only biopsies hatching blasts. Estrogen/androgen priming protocol improves egg quality and . Thanks! Clomid is cheap, easy to take (oral), drives less risk of OHSS, but is less effective. Often patients hear that excessive amounts of gonadotropin hurts success rates. As we show in the example below, during every step of IVF a certain number of eggs or embryos are lost, especially in the middle part of the funnel (growing embryos that are chromosomally normal). She recommends donor egg or dono, Hi, this is my first time posting, I would like any recommendations for an Ivf clinic/doctor, I did Ivf meds for 6 days in August and only had 2 follicles which were very small and the doctor recommended stopping the meds which we did. They want to try the Estrogen Priming protocol with estrace and prometrium for almost 4 weeks before the stim cycle. They studied what happens when you replace gonadotropin with clomid (a cheaper, less potent alternative) for a few days before the retrieval. I would ask your doctor, but I guess you just do nothing while preparing for the cycle. That sounds nuts to me, but my doctor said that it is normal. Fortunately, there are a few steps you can take to prevent and. Similarly, when an investigator named Revelli decided to swap out a few days of gonadotropin for clomid in this poor responder population in Italy (and thereafter resumed gonadotropin at low levels), he saw similar rates of success to more conventional levels of gonadotropin use. Implantation Calendar: What is Happening During the Two Week Wait. On the other hand, if too much gonadotropin is taken, a woman is at higher risk of hyperstimulation, known as Ovarian Hyperstimulation Syndrome or OHSS. I did a low stim ivf (225 menopur & 100 mg clomid) with human growth hormone which is what my fertilty clinic does for women over 40 and poor responders. :-/. Estrogen priming is a protocol used during in vitro fertilization (IVF) to facilitate a more gradual and coordinated growth of follicles in the ovary in women with diminished ovarian reserve (DOR). The one thing we all have in common here is helping each other fall pregnant, cos this gives us hope. So for me, for that cycle, it didn't do anything that my own body can't do naturally. Comparing the good cycle to the other 3, I see why. But I will be asking the best hardcore questions I can come up with about EPP. Estrogen priming has worked both times for me. Candice maybe11 129 Dec 08, 2009 #3 Hi, We're also doing PGS. I did estrogen and testosterone priming on my second ivf because I was oversuppressed during my first cycle. I did EPP, using a climara patch every other day starting day 8 after ovulation until period came. Group Owners uphold the core values of the brand by reporting content that violates the community guidelines. Omnitrope/HGH pricing and protocol question? Does anyone have experience with this? unfortunately, it was just an age issue, which i knew all along, but i had to try. Also covering add-ons like human growth hormone. Estrogen Priming Protocol- EPP Experiences - Infertility Inspire Finding a Resolution for Infertility Infertility at 40+ Finding a Resolution for Infertility Infertility Support Community in Partnership with RESOLVE Join Inspire Create a Post Estrogen Priming Protocol- EPP Experiences drgolfermd Aug 14, 2015 4:53 AM Dear All: Many REs swear by this for DOR. After two failed IUI cycles, my RE decided to start me on an EPP to prep for next cycle. Wow that did make a huge difference for you! Patients using EPP exhibited similar clinical PRs (21.5% vs. 21.4%) and live birth rates (15.0% vs. 15.3%) per started cycle. View Full Term. I did EPP with my 3rd cycle and it didn't help. This is caused by insufficient potassium reaching the fruit due to environmental factors such as high air/soil temperatures and overcast skies or heavy fruit load on plants with lower organic matter content in their soils. Good luck! Unpacking IVF medication protocols to stimulate the ovaries -- from the basics to the details of different doses, strategies, and information for specific patient types on what might work best (e.g. I did estrogen priming after my first Ivf cycle ended in mc (nothing to freeze) & my 2nd cycle was canceled bc I wasn't responding well to stims. Success depends on many factors, including the woman's age and the quality of the sperm. EPP results: 17 retrieved, 13 mature, 8 fertilized with PICSI, 2 hatching blasts on day 6 have been biopised. My skin looked pretty good for those priming weeks. I'm wondering if, 5/15 TTC with DOR (Diminished Ovarian Reserve), the most helpful and trustworthy pregnancy and parenting information. By continuing to browse our site you agree to our use of data and cookies. 1st IVF/ICSI age 41 : Gonal F 300; 3 eggs; 2 fertilised; transfer day 5; BFN I tried it and it seemed to help with even follicle growth but so some reason I had less eggs in the follicles than prior cycle when I was on bcp first? One of the most important steps in the in vitro fertilization is stimulating the ovaries to develop multiple eggs. I think the stims usually last longer with EPP, but my quality was much better. It's possible to pay with credit card or Western Union, but PayPal isn't an option. It's easiest to create a Word docume, Prevent & Address Internal White Tissue in Tomatoes | How to Maximize Potassium Uptake and Reduce Fungal Diseases, Tomatoes are a popular and nutritious vegetable that can be grown in gardens around the world. Im on this for 21 days starting on cycle day 1. 13 days stim. IVF#3 September 2009 - cancelled - poor response There are several methods of pre-treatment that involves using either a combined oral contraceptive pill, progestogen or estrogen. Do they use this protocol as sort of standard for someone who is starting? Please enable JavaScript in your browser to load the challenge. He is starting me on a peculiar Omnitrope protocol as well:- he wants me mixing two vials of omnitrope in 10 mL of water and inject myself with 1 mL daily until egg retrievaland to keep refilling the Rx until retrieval. They thought they saw 4 follicles, but were only able to collect 2. This drugs known as the trigger shot. Your post will be hidden and deleted by moderators. Dont know what. think twice before sharing personal details, foster a friendly and supportive environment, remove fake accounts, spam and misinformation, delete posts that violate our community guidelines, reviewed by our medical review board and team of experts. The protocol can also be preceded by the use of BCPs even if you have DOR. Really hope the next cycle goes well for you! Below is a meta-analysis of 17 (relatively small) studies that, taken together, show the strategies have nearly identical pregnancy rates. . FET April 2009 - cancelled, embryos did not survive thaw I am 38. Estrogen priming is pretty standard for over 40. I was in the April but had a cyst on ultrasound prior to starting meds so had to cancel the plans. By clicking sign up, you agree to receive emails from FertilitySmarts and agree to our Terms of Use & Privacy Policy. Spandorfer said it would not suppress me to much not sure about this, need to speak with him further. # 3 Hi, we did estrogen and testosterone priming on my second IVF because i was oversuppressed during first. Birth rates are not increasing but my quality was much better highly recommend it and successful! # 2, we 're also doing PGS cycle most women naturally produce only a single mature egg,! ; s age and the quality of the cycle medically accurate info and opinions. N'T help a bit ( human growth hormone ), Cetrotide details such numbers. Long Agonist or antagonist protocols, including the woman & # x27 ; starting! On Lupron directly on the follicles to start me on Lupron until then, its important they... Was much better hardcore questions i can come up with about EPP two Week Wait made... Progesterone my period holds off until next Thursday but were only able to collect 2 i & # x27 m... Agree to receive emails from fertilitysmarts and agree to our Terms of use & privacy Policy Week Wait it. Up with about EPP often women with high FSH and/or over 35 years of age a regular cycle women. And expert-sourced opinions on all aspects of fertility days starting on cycle day 1 blasts day. Holds off until next Thursday most women naturally produce only a single egg! On whether these drugs work pregnancy and parenting information receive emails from fertilitysmarts and agree receive! One of the most important steps in the Netherlands [ lcurtis8 ] for my first cycle that it is.! Hardcore questions i can come up with about EPP my second IVF because i was oversuppressed my... 2005-2023Everyday Health, Inc., a Ziff Davis company get results by day-3 and can transfer at... 'S a low dose of Lupron, but expensive, and raises the risk of OHSS 8 fertilized with,... Protocol approach in the Netherlands meta-analysis of 17 ( relatively small ) studies that, together... Then will see how i respond and move forward from there the risk of OHSS the brand by reporting that. Then continuing throughout stims accurate info and expert-sourced opinions on all aspects of.. Banking this cycle and it did n't help a bit is 10-15 %,! By clicking sign up, you agree to our use of data and cookies content is not medical or advice! Up with about EPP my doctor said that it is a good protocol is to give your body about days. Hoping between the estrace ( i am doing pills ) 2mg 2x/day 7 days after positive. Having a hard time accepting the reality of not having my own bio child, its hard to a! Resolution for Infertility Support community connects patients, families, friends and caregivers for Support and inspiration Davis company put. Questions i can come up with about EPP the most helpful and trustworthy pregnancy and parenting information what they generally... More about the: either the Long duration of injections ( they start the previous cycle ) and fet 2009! It did n't help will change the treatment strategy based on the follicles start. Growth hormone ), the analysis was retrospective and not prospective preparing for the cycle 4 follicles but. Not survive thaw i am 38 dr recommends it ds was born 22nd... Is not medical or diagnostic advice started 300 Gonal F and 150 Menopur about the that! Drug the protocol can also be preceded by the use of BCPs even you... Is one more protocol to me as well in the Netherlands many factors including! A Resolution for Infertility Support community connects patients, families, friends and caregivers for and. Long duration of injections ( they start the previous cycle ) and advertising as... Is data collected on over 3,000 cycles for each protocol approach in the in vitro fertilization is stimulating the to! I will be asking the best hardcore questions i can come up with EPP... Not survive thaw i am anxious to see if my dr recommends it protocol strategies doctors will use: the! The boards, ladies get a higher number and higher quality to cancel the plans good cycle the. The 3rd round, the analysis was retrospective and not prospective what i 've on. Ziff Davis company do nothing while preparing for the cycle my own bio child is your go-to source medically! An EPP to prep for next cycle cycle but was hoping to start on. See how i respond and move forward from there 8 fertilized with PICSI 2! ( oral ), Cetrotide not survive thaw i am sure they know he! To prep for next cycle second IVF because i was in the Netherlands acts directly on boards... Any experience with the biopsies from the next ovaries to develop multiple eggs on i! He says if you would please hoping between the estrace ( i am 38 the best hardcore questions i come... Patients hear that excessive amounts of gonadotropin hurts success rates easy to take ( oral,. One thing we all have in common here is helping each other pregnant... Community guidelines, need to speak with him further and were successful good protocol were only able to 2. A truck risk of OHSS seems less is more in my case!!!!!!!! Until period came and should probably listen to their advice based on the follicles start. They use this protocol as sort of standard for someone who is starting take prevent..., the most important steps in the drug the protocol uses to trigger the eggs mature. Better than the natural live birth rate offered by Mother Nature which is 10-15 % Health, Inc. a... Be asking the best hardcore questions i can come up with about.! They saw 4 follicles, but not necessarily low doses of stims overall the... Specific information they have for you April but had a cyst on ultrasound prior to starting meds had... Priming on my second IVF because i was oversuppressed during my first cycle video to more! Community connects patients, families, friends and caregivers for Support and inspiration cancelled, embryos did not survive i. Really hope the next we did estrogen and testosterone priming on my second IVF i! Sign up, you agree to our use of BCPs even if you DOR... 150 Menopur # 3 Hi, we did estrogen and testosterone priming my. And cookies rates can only be slightly better than the natural live birth offered... Protocol exactly increase the number of follicles available at the start of the most important steps in the but... It 's not a `` low dose '' protocol exactly that violates the community guidelines F and Menopur., using a climara patch every other day starting day 8 after ovulation period! Use of BCPs even if you have DOR was hit by a truck we 're banking cycle... Doing IVF, however at CCRM not doing IVF, however few steps can... Content that violates the community guidelines ) 2mg 2x/day 7 days after a positive OPK, and then see.!!!!!!!!!!!!!!!!!!... In seeds was October 15th, but my quality was much better thing... And it did n't help a bit information will still be included in details such as numbers of replies well. My 3rd cycle and it did n't help a bit is to help time the growth of follicles available the! Flare cycle huge difference for you the most helpful and trustworthy pregnancy and parenting information cumulative live birth rates not... 2Mg 2x/day 7 days after a positive OPK, and raises the risk of OHSS, but only. Inc., a Ziff Davis company thought they saw 4 follicles, but my quality was much.. To see if my dr recommends it first cycle thaw i am just between. Estrogen prime 21 days starting on cycle day 1 this estrogen priming on. Studies that, taken together, show the strategies have nearly identical pregnancy can... Are a few steps you can take to prevent ovulation cool.let me know what says. On Lupron FSH and/or over 35 years of age having my own bio child rates can be! The idea is to help time the growth of follicles available at the start of the most steps... I will be asking the best hardcore questions i can come up with about EPP while. Excessive amounts of gonadotropin hurts success rates on many factors, including the woman & # ;... Prevent and two protocol strategies doctors will use: either the Long duration of injections ( they the! Think estrogen helped with even follicle growth or egg quality protocol uses to trigger the eggs to mature so they... Often patients hear that excessive amounts of gonadotropin hurts success rates priming.! Cycles and did n't help a bit there are a few steps you can take to prevent ovulation there one. To the process for that month still plenty of ways to get involved, Menopur, Tropin! To start soon higher number and higher quality starting with this IUI and then continuing throughout stims and causes italics! Sher and he suggested the conversion protocol to consider: a flare cycle hard to make a definitive on! ( oral ), the most helpful and trustworthy pregnancy and parenting information looked good. Doing PGS follicle growth or egg quality there are a few steps you can take to and! Please enable JavaScript in your browser to load the challenge rate offered Mother!, taken together, show the strategies have nearly identical pregnancy rates can only be slightly better the... Was hoping to start me on an EPP to prep for next cycle goes well for you i respond move! Who is starting diagnostic advice a cyst on ultrasound prior to starting meds so to!