Negative reactions such as vomiting, diarrhea, and tremors were only observed at supratherapeutic (higher than recommended) doses. I have been raising and showing collies for 40+ years but am always open to learning. Their cheek swab collection, multiple dog discounts, and printable results sent straight to email all make the process very simple and convenient. Her treatment plan included taking him off Nexgard, and the seizures stopped. THANK YOU, THANK YOU, THANK YOU! Unless youre, say, an expat living in China, you can definitely find a better option. 3,4,7-9 Most notably, a series of randomized . Hartz products generally dont seem to get very favorable reviews either. Simparica Trio is a tasty monthly chew that provides protection against the biggest threats facing our dogs; fleas, ticks, intestinal worms and deadly heartw. Simparica TRIO requires a prescription from your veterinarian. Simparica is administered once a month as a flavored chewable. To give Sentinel a boost, I recommend using it in conjunction with a weekly topical spray like Natural Chemistry. (Just bear in mind that Preventic contains amitraz, which is toxic to cats.). So the following month we tried Interceptor Plus and it was fine. I went through Paw Print Genetics to save money. , Emily, thanks for a very helpful and informative article. In my opinion, this spray is great combined with anything since it has repellent properties and smells delightful. Unless your dogs are exposed to untreated stray or wild animals who are carrying fleas through the winter months, there is no need to give parasite protection to your pets year round. Veterinary pharmacists are not very common and there might not be any in your area, but many pharmacies are willing to ship medications. Simparica Trio Chewable Tablets for Dogs is recommended for use in dogs and puppies 8 weeks of age and older, and weighing 2.8 lbs or more for the prevention of heartworm disease caused by Dirofilaria immitis. My border collie started having seizures (he was on Bravecto AND Sentinel) and the vet never said anything about the gene mutation. My two cats were father and son so probably carried the same gene. I have two Rough Collies who are MDR1 carriers and an Aussie mix, so I have a vested interest in everything Ive researched. That being said, I do have to give the disclaimer that Im not a veterinarian myself. Thank you for this. I have two beautiful rough collies & of course always want to keep them safe. Great summary! Also I live in Michigan just outside Detroit so his walks consist of concrete sidewalks and no real wildlife to come across. I actually just updated the section on Seresto collars today with new info and a link to a USA Today article about side effects resulting in seizures and even death. Thanks Im a dog mom to two Pyrs, Border collie and a brand new 12 week Australian Shephard/Pyr mix. Im glad you found it helpful. On the downside, its efficacy only lasts for about a day. After 24 hours, it is considered waterproof and a bath, while alleviating some effects, will not offer as much relief. Some swear by food grade DE (diatomaceous earth) as a natural dewormer of roundworms, hookworms, whipworms, and even tapeworms. MDR1 FAQs. ? Is the Frontline the one listed in the article ok in a multi dog family where there is a risk of one licking it off the other? Fleas this summer in my part of CA are particularly bad. Tap to zoom. Its in lots of grain-based foods because lots of grains are stored with diatomaceous earth to keep the bugs from eating the grain.. Its a nice alternative to Vectra 3D since its not as potent (so less chance for irritation), yet it also has some repellent properties. I grew up in Michigan, and we always discontinued pest products during the cold season. Get new post updates in monthly email newsletters. My dog has been tested and is mutant/normal (MDR1). I tried Seresto with my girl and she had a seizure. A good spritz-down before you and your girl go into the woods should repel the ticks. If you think about it, come back here and let me and other readers know what worked best for you! ? I would actually place it in the caution category, since if a dog who had an active heartworm infection was given diethylcarbamazine (Dimmitrols main ingredient) it could suffer severe side effects and even die. Apparently, it affects certain cats with a certain gene. We are now on the second month of using this, but I've started seeing posts and . Just checking in to see how you and your pup are doing and if you ended up using Seresto collars or not. 1x 20mg tablet for 11.1 to 22 pounds. Simparica Trio Dosage. Simparica Trio is replacing NexGard Spectra as your dog's monthly parasite protection. Advantage takes care of fleas at all life stages and is even supposed to kill them on contact, and it also covers lice. She had a severe reaction with diarrhea, drooling, depression etc. Material name: Simparica Trio Version #: 01 Issue date: 07-01-2019 SDS US. All but one (5 of 6) of the Simparica Trio-treated dogs were negative for D. immitis antigen and MF on day 180, while the remaining dog was positive for the antigen but negative for MF for this day. Our vet who really pushes natural (Chinese) medicine for pets, recommended Bravecto for our collies after the Seresto collars were simply not working for Roxie (6 ticks in 2 months even with trying a second Seresto collar thinking the first one might be defective). I found this after hearing about the Seresto issues and how they werent accurately reporting data. Excellent research and well written article! Based on your email address Im going to guess that you breed or have bred wolfdogs in the past, and Im pretty sure theyre a bit tougher than your average Collie. Thank you for your time and efforts to provide useful knowledge on flea & tick products for our sweet colliesAppreciate your time. Also, it might be helpful for you to go to the Quick Nav box near the top of the article and just read or reread the intro and the sections on heartworm meds and oral flea/tick meds if you want a deeper understanding of this topic. It seems unlikely for that much time to elapse before a reaction, but I would definitely consult with a veterinarian. Happy to be of help! Several clinical trials funded by Zoetis published shortly after drug approval showed impressive results concerning safety and incidence of adverse effects in dogs. Revolution, along with a product called Stronghold, tested safest in clinical trials of heartworm medications. Simparica TRIO was approved by the U.S. Food and Drug Administration's (FDA) Center for Veterinary Medicine in March 2020. I like to sprinkle some around the perimeter of my yard and lay an inner circle around the edges of my house which probably looks like Im trying to keep out evil fairies and other fantasy creatures. That being said, if a dog was known to be heartworm-negative and the dogs owner would remember to administer a daily dose, I think it could make a good alternative heartworm preventive. From the standpoint of MDR1 dogs, it is safe. Safe in avermectin-sensitive collies and dogs with the MDR1 gene; - It is easy to administer, with no need for pre-treatment or fasting. The neurological problems tied to Simparica scare the shit out . I will try to find the article again, I stupidly didnt bookmark it. Multi-Drug Resistance 1 (MDR1) is a gene that is meant for helping to protect the brain. Another thing to research and to ask your personal vet about might be potential drug/drug interactions between the Trazadone and Effifax, or whichever parasite preventives you choose to use in the future. They said Frontline Plus doesnt really work anymore like it used too. I had never heard of Dimmitrol before, but I did some research after reading your comment. Most veterinarians in my area are still prescribing Bravecto, simply because they arent yet comfortable enough with Credelio. GestorVet es el futuro de la gestin veterinaria. Both of those products should definitely be more effective than the Frontline Plus. 4.11 Withdrawal period(s) Though all of these medicines had previously been approved by FDA scientists, now data received by the agency indicates that some animals receiving Bravecto, Nexgard, or Simparica have experienced adverse events such as muscle tremors, ataxia, and seizures.. Simparica: The manufacturer of Simparica has tested the product for safety in dogs with the MDR1 . Eliminate fleas before they lay eggs. One downside of this medicine is that it will not eliminate adult fleas or ticks, so it might need to be used in combination with products likeCapstaror an insect repellent spray. Thats a rough situation, and Im sorry you and your pup are going through this. I know it contains Ivermectin, so I am not sure this information is correct. (CAS 112945-52-5) Oral Acute LD50 Rat > 22500 mg/kg Skin corrosion/irritation Prolonged skin contact may cause temporary irritation. Simparica TRIO. This gave me a great start for research. Best of luck with your girl! This product is not recommended for MDR1 dogs, as its main ingredient, dinotefuran, is a harsh pesticide. To make dosing easy, it's available for dogs in six sizes based on body weight range: Gold: 2.8-5.5 pounds. Altogether, the agency received 75,000 incident reports, the majority of which were complaints of skin reactions in both animals and humans. Please tell me which is the safest! Sarolaner had been approved in 2016 to treat flea and ticks, moxidectin . Unlike many other external parasite treatments that only kill little bloodsuckers after theyve bitten the dog, K9 Advantix claims to kill them on contact. Selamectin is their shared main ingredient. (More on those later.). I have a 3 year old and an 11 week old Australian Shepherd. I am currently fostering 3 rescued puppy mill border collie females with sarcoptic mange. My personal quest to find the safest parasite protection for dogs known to carry the MDR1 (Multi Drug Resistance) gene led me on a merry chase. Thanks for your informative article. Iubitorii de animale pot comanda produsul Simparica Trio Caini (40.1 - 60 kg), 3 x comprimate masticabile la orice or din zi sau din noapte. I never knew flea/tick control was so complicated, until I started reading! I thought I initially replied to your comment back in December, but I was just reviewing the comments section and it looks like my reply never posted! For long-term arthritis, my vet tech friend has had a lot of success giving her senior dog a regular Glucosamine supplement. Simparica is safe for Australian Shepherds and offers a number of benefits, including: -It is fast-acting and begins to kill fleas within hours. I have an 8 year old BC and a 12 week old English Shepherd/Rough Collie mix. 5,10 That's two tasty chews to double your dog's dosing delight each month. Another danger often lies in a treated dog being exposed to additional environmental pesticides, which can lead to an accidental overdose. I didnt see the link for the drug compatibility. The 10 Best Ways to Get Rid of & Prevent Ticks on Dogs. HEARTGARD Plus real-beef chews are the delicious, #1 vet-recommended heartworm disease preventive - and pair perfectly with #1 vet-recommended NexGard (afoxolaner) chews. (The Environmental Protection Agency is responsible for approving external flea and tick products.) My question is this Is it the heartworm component of the combination heartworm/flea pill or is it the flea component? The caution is specifically for cats since Advantix contains Permethrin, which is toxic to them. Another safe heartworm medication is the daily dimmitrol. Hi Vicki, ? I understand that most dogs are not having negative side effects as a result of using Bravecto, Nexgard, or Simparica but enough dogs are. It was winter. 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